pISSN: 1976-4251
eISSN: 2233-4998
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CARBONLETT, vol. 27, no. 1, pp.18-25, 2018

DOI: http://dx.doi.org/ DOI:10.5714/CL.2018.27.018

Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate

Shou-Cang Shen1,♠, Wai Kiong Ng1, Kumaran Letchmanan1, Ron Tau Yee Lim1 and Reginald Beng Hee Tan1,2,♠

Affiliation: 1Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), Singapore 627833
2Department of Chemical and Biomolecular Engineering, The National University of Singapore, Singapore 117576

Abstract: In this study, graphene oxide(GO) was used as drug carriers to amorphize poorly watersoluble drugs via a co-spray drying process. Two poorly water-soluble drugs, fenofibrate and ibuprofen, were investigated. It was found that the drug molecules could be in the graphene nanosheets in amorphous or nano crystalline forms and thus have a significantly enhanced dissolution rate compared with the counterpart crystalline form. In addition, the dissolution of the amorphous drug enwrapped with the graphene oxide was higher than that of the amorphous drug in activated carbon (AC) even though the AC possessed a larger specific surface area than that of the graphene oxide. The amorphous formulations also remained stable under accelerated storage conditions (40°C and 75% relative humidity) for a study period of 14 months. Therefore, graphene oxide could be a potential drug carrier and amorphization agent for poorly water-soluble drugs to enhance their bioavailability.


Keyword: graphene oxide, capsulation, dissolution rate, crystallinity, physical stability