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CARBONLETT, vol. 27, no. 1, pp.26-34, 2018

DOI: http://dx.doi.org/ DOI:10.5714/CL.2018.27.026

Assembly of chemically reduced graphene oxide with folic acid functionalized with pyrene moieties and electrochemical sensing of folate receptors

Binhee Kwon1, Jongyeap Park1, Woojun Jeong1, Guembi Jeong1, Hyeong Seon Ryu2, Peerasak Paoprasert3,♠, Sung Young Park1,4,♠ and Insik In1,5,♠

Affiliation: 1Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation, Chungju 27469, Korea
2Department of Organic and Nano Engineering, Hanyang University, Seoul 04763, Korea
3Department of Chemistry, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, Thailand
4Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 27469, Korea
5Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 27469, Korea

Abstract: To formulate folate receptor (FR)-specific graphene-based electrochemical electrodes, a folic acid (FA) derivative attached with two pyrene molecules on the glutamate tail of FA was synthesized. The resulting pyrene-functionalized FA (FA-Py) presented the spontaneous noncovalent binding on chemically reduced graphene oxides (rGO) through an π-π interaction. Ultrathin morphology, high water-resistance, and preservation of intact FR-specific pteroates from the rGO/FA-Py assembly allow this assembly to be exploited as robust and FR-specific electrochemical electrode materials. The limits of detecting rGO/FA-Py modified electrodes were found to be as low as 3.07 nM in FR concentrations in cyclic voltammetry analysis.

Keyword: chemically reduced graphene oxide, noncovalent interaction, electrochemical sensing, folic acid, folate receptor