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CARBONLETT, vol. 27, no. 1, pp.50-63, 2018

DOI: http://dx.doi.org/ DOI:10.5714/CL.2018.27.050

Potentiometric sensor of graphene oxide decorated with silver nanoparticles/molecularly imprinted polymer for determination of gabapentin

Nehad A. Abdallah1,2,♠ and Heba F. Ibrahim2

Affiliation: 1Pharmacognosy and Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 41477, KSA
2Experiments and Advanced Pharmaceutical Research Unit, Faculty of Pharmacy, Ain Shams University, Cairo 1156, Egypt

Abstract: An imprinted potentiometric sensor was developed for direct and selective determination of gabapentin. Sensor is based on carbon paste electrode adapted by graphene oxide that is decorated with silver nanoparticles and mixed with molecularly imprinted polymers nanoparticles using gabapentin as a template molecule. The synthesized nanoparticles were characterized by Fourier transmission infrared spectroscopy, transmission electron microscopy and X-ray diffraction. Under optimal experimental conditions, the studied sensor exhibited high selectivity and sensitivity with LOD of 4.8×10-11 mol L-1. It provided a wide linearity range from 1×10-10 to 1×10-3 mol L-1and high stability for more than 3 mo. The sensor was effectively used for the determination of gabapentin in pharmaceutical tablets and spiked plasma samples.

Keyword: gabapentin, molecular imprinted nanoparticles, graphene oxide, sensor